Loss of tumor-suppressive function during chemically induced neoplastic progression of Syrian hamster embryo cells.
نویسندگان
چکیده
منابع مشابه
Effects of tumor-promoting phorbol diesters on neoplastic progression of Syrian hamster embryo cells.
The progression of normal Syrian hamster embryo cells to a neoplastic phenotype after treatment with a chemical carcinogen and continuous exposure to phorbol ester tumor promoters was studied in cell culture. Tumor promoters were able to rescue cell lines derived from individual carcinogen-treated colonies from a program of cellular senescence. In general, these cell lines did not grow in soft-...
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In these studies, Syrian hamster embryo cells (SHE), which were isolated at different stages of neoplastic progression, were used to test the ability of the protein phosphatase inhibitors, okadaic acid and sodium orthovanadate (Na3VO4) to induce neoplastic progression. We observed that these chemicals can induce transition of the cells from one stage to the other at different points in the mult...
متن کاملNeoplastic transformation of mouse C3H 10T1/2 and Syrian hamster embryo cells by heavy ions.
C3H 10T1/2 mouse-embryo fibroblasts were used for transformation experiments to study the effectiveness of various heavy ions with energies up to 20 MeV/u and LET values from 170 to 16,000 keV/micrometers. The transformation frequency per unit absorbed dose decreased with increasing ionization density; at the highest values of LET we found a decrease even of the transformation efficiency per un...
متن کاملMultistage neoplastic transformation of Syrian hamster embryo cells cultured at pH 6.70.
We have reported that the frequency of induction of the morphologically transformed phenotype in early passage Syrian hamster embryo cells is increased in carcinogen-treated cultures when the cells are cultured in media of pH 6.70, instead of the traditionally used pH 7.35. The purpose of the studies reported here was to determine the neoplastic potential of cells derived from colonies of morph...
متن کاملIdentification of genes associated with tumor suppression in Syrian hamster embryo cells.
Loss of a tumor-suppressor gene function appears to play a critical role in the multistep process of neoplastic transformation of Syrian hamster embryo (SHE) cells in vitro. Clonal variants of two independent, preneoplastic cell lines have been isolated that have either retained (termed supB+) or lost (termed supB-) the ability to suppress the tumorigenicity of a highly malignant benzo[alpha]py...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1986
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.83.16.5992